{"id":278,"date":"2026-04-11T10:40:42","date_gmt":"2026-04-11T10:40:42","guid":{"rendered":"https:\/\/luciuspharmacy.com\/?post_type=product&p=278"},"modified":"2026-09-30T18:58:48","modified_gmt":"2026-09-30T18:58:48","slug":"lucivos-ivosidenib-250-mgx60-tablets","status":"publish","type":"product","link":"https:\/\/luciuspharmacy.com\/pt\/product\/lucivos-ivosidenib-250-mgx60-tablets\/","title":{"rendered":"LuciVos"},"content":{"rendered":"

HIGHLIGHTS OF PRESCRIBING INFORMATION <\/strong><\/span><\/p>\n

These highlights do not include all the information needed to use LUCIVOS safely and effectively. See full prescribing information for LUCIVOS.<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

INDICATIONS AND USAGE<\/strong><\/strong><\/span><\/p>\n

LUCIVOS is an isocitrate dehydrogenase-1 (IDH1) inhibitor indicated for patients with a susceptible IDH1 mutation as detected by an FDA-approved test with: <\/span><\/p>\n

Newly Diagnosed Acute Myeloid Leukemia (AML) <\/span><\/p>\n

\u2022 In combination with azacitidine or as monotherapy for the treatment of newly diagnosed AML in adults 75 years or older, or who have comorbidities that preclude use of intensive induction chemotherapy. <\/span><\/p>\n

Relapsed or refractory AML <\/span><\/p>\n

\u2022 For the treatment of adult patients with relapsed or refractory AML. <\/span><\/p>\n

Locally Advanced or Metastatic Cholangiocarcinoma <\/span><\/p>\n

\u2022 For the treatment of adult patients with locally advanced or metastatic cholangiocarcinoma who have been previously treated .<\/span><\/p>\n

 <\/span><\/p>\n

DOSAGE AND ADMINISTRATION<\/strong><\/strong><\/span><\/p>\n

500 mg orally once daily with or without food until disease progression or unacceptable toxicity. Avoid a high-fat meal.<\/span><\/p>\n

 <\/span><\/p>\n

DOSAGE FORMS AND STRENGTHS <\/strong><\/strong><\/span><\/p>\n

Tablets: 250 mg\u00d760 tablets<\/span><\/p>\n

 <\/span><\/p>\n

CONTRAINDICATIONS <\/strong><\/strong><\/span><\/p>\n

None.<\/span><\/p>\n

 <\/span><\/p>\n

WARNINGS AND PRECAUTIONS <\/strong><\/strong><\/span><\/p>\n

\u2022 QTc Interval Prolongation: Monitor electrocardiograms and electrolytes. If QTc interval prolongation occurs, dose reduce or withhold, then resume dose or permanently discontinue LUCIVOS. <\/span><\/p>\n

\u2022 Guillain-Barr\u00e9 Syndrome: Monitor patients for signs and symptoms of new motor and\/or sensory findings. Permanently discontinue LUCIVOS in patients who are diagnosed with Guillain-Barr\u00e9 syndrome.<\/span><\/p>\n

 <\/span><\/p>\n

ADVERSE REACTIONS <\/strong><\/strong><\/span><\/p>\n

The most common adverse reactions including laboratory abnormalities (\u226525%) in patients with AML are leukocytes decreased, diarrhea, hemoglobin decreased, platelets decreased, glucose increased, fatigue, alkaline phosphatase increased, edema, potassium decreased, nausea, vomiting, phosphate decreased, decreased appetite, sodium decreased, leukocytosis, magnesium decreased, aspartate aminotransferase increased, arthralgia, dyspnea, uric acid increased, abdominal pain, creatinine increased, mucositis, rash, electrocardiogram QT prolonged, differentiation syndrome, calcium decreased, neutrophils decreased, and myalgia. <\/span><\/p>\n

 <\/span><\/p>\n

The most common adverse reactions (\u226515%) in patients with cholangiocarcinoma are fatigue, nausea, abdominal pain, diarrhea, cough, decreased appetite, ascites, vomiting, anemia, and rash. <\/span><\/p>\n

 <\/span><\/p>\n

The most common laboratory abnormalities (\u226510%) in patients with cholangiocarcinoma are hemoglobin decreased, aspartate aminotransferase increased, and bilirubin increased.<\/span><\/p>\n

 <\/span><\/p>\n

DRUG INTERACTIONS <\/strong><\/strong><\/span><\/p>\n

\u2022 Strong or Moderate CYP3A4 Inhibitors: Reduce LUCIVOS dose with strong CYP3A4 inhibitors. Monitor patients for increased risk of QTc interval prolongation. <\/span><\/p>\n

\u2022 Strong CYP3A4 Inducers: Avoid concomitant use with LUCIVOS. <\/span><\/p>\n

\u2022 Sensitive CYP3A4 substrates: Avoid concomitant use with LUCIVOS. <\/span><\/p>\n

\u2022 QTc Prolonging Drugs: Avoid concomitant use with LUCIVOS. If co-administration is unavoidable, monitor patients for increased risk of QTc interval prolongation.<\/span><\/p>\n

 <\/span><\/p>\n

USE IN SPECIFIC POPULATIONS <\/strong><\/strong><\/span><\/p>\n

Lactation: Advise women not to breastfeed.<\/span><\/p>\n

 <\/span><\/p>\n

Storage <\/strong><\/strong><\/span><\/p>\n

Store at 20\u2103 to 25\u2103 (68\u2109 to 77\u2109), excursions permitted between 15\u2103 and 30\u2103 (59\u2109 and 86\u2109) [see USP Controlled Room Temperature]. Protect from moisture. <\/span><\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

LuciVos contains ivosidenib, an IDH1 inhibitor. Each pack contains 60 tablets of 250 mg. Review the full product details and consult your clinician before ordering with a valid prescription.<\/p>","protected":false},"featured_media":2123,"comment_status":"open","ping_status":"closed","template":"","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":""},"product_brand":[],"product_cat":[37],"product_tag":[],"class_list":["post-278","product","type-product","status-publish","has-post-thumbnail","product_cat-cholangiocarcinoma","first","instock","shipping-taxable","purchasable","product-type-simple"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/luciuspharmacy.com\/pt\/wp-json\/wp\/v2\/product\/278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/luciuspharmacy.com\/pt\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/luciuspharmacy.com\/pt\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/luciuspharmacy.com\/pt\/wp-json\/wp\/v2\/comments?post=278"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/luciuspharmacy.com\/pt\/wp-json\/wp\/v2\/media\/2123"}],"wp:attachment":[{"href":"https:\/\/luciuspharmacy.com\/pt\/wp-json\/wp\/v2\/media?parent=278"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/luciuspharmacy.com\/pt\/wp-json\/wp\/v2\/product_brand?post=278"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/luciuspharmacy.com\/pt\/wp-json\/wp\/v2\/product_cat?post=278"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/luciuspharmacy.com\/pt\/wp-json\/wp\/v2\/product_tag?post=278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}