{"id":598,"date":"2026-04-12T15:32:34","date_gmt":"2026-04-12T15:32:34","guid":{"rendered":"https:\/\/luciuspharmacy.com\/?post_type=product&p=598"},"modified":"2026-08-30T03:53:25","modified_gmt":"2026-08-30T03:53:25","slug":"lucipac-pacritinib-100-mgx120-capsules","status":"publish","type":"product","link":"https:\/\/luciuspharmacy.com\/ru\/product\/lucipac-pacritinib-100-mgx120-capsules\/","title":{"rendered":"LuciPac"},"content":{"rendered":"

HIGHLIGHTS OF PRESCRIBING INFORMATION <\/span><\/p>\n

These highlights do not include all the information needed to use LuciP<\/span>ac<\/span> safely and effectively. See full prescribing information for LuciP<\/span>ac<\/span>.<\/span><\/span><\/p>\n

 <\/span><\/p>\n

INDICATIONS AND USAGE<\/span><\/strong><\/strong><\/span><\/p>\n

LuciPac is a kinase inhibitor indicated for the treatment of adults with intermediate or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis with a platelet count below 50<\/span>\u00d7<\/span>10<\/span>9<\/span><\/sup>\/L . <\/span><\/span><\/p>\n

This indication is approved under accelerated approval based on spleen volume reduction. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).<\/span><\/p>\n

 <\/span><\/p>\n

DOSAGE AND ADMINISTRATION<\/span><\/strong><\/strong><\/span><\/p>\n

\u2022<\/span>  Recommended dosage is 200 mg orally twice daily. <\/span><\/span><\/p>\n

\u2022<\/span>  May be taken with or without<\/span> food.<\/span><\/span><\/p>\n

 <\/span><\/p>\n

DOSAGE FORMS AND STRENGTHS <\/span><\/strong><\/strong><\/span><\/p>\n

Capsules: <\/span>100<\/span> mg\u00d7<\/span>120<\/span> capsules<\/span><\/span><\/p>\n

 <\/span><\/p>\n

CONTRAINDICATIONS <\/span><\/strong><\/strong><\/span><\/p>\n

Concomitant use of strong CYP3A4 inhibitors or inducers<\/span>.<\/span><\/span><\/p>\n

 <\/span><\/p>\n

WARNINGS AND PRECAUTIONS <\/span><\/strong><\/strong><\/span><\/p>\n

\u2022<\/span> <\/span>Hemorrhage: Avoid use in patients with active bleeding and hold LuciPac prior to any planned surgical procedures. May require dose interruption, dose reduction or permanent discontinuation depending on severity. <\/span><\/span><\/p>\n

\u2022<\/span> <\/span>Diarrhea: Manage significant diarrhea with anti-diarrheals, dose reduction, or dose interruption. <\/span><\/span><\/p>\n

\u2022<\/span> <\/span>Thrombocytopenia: Manage by dose reduction or interruption. <\/span><\/span><\/p>\n

\u2022<\/span> <\/span>Prolonged QT Interval: Avoid use in patients with baseline QTc >480 msec. Interrupt and reduce LuciPac dosage in patients who have a QTcF >500 msec. Correct hypokalemia prior to and during LuciPac administration. <\/span><\/span><\/p>\n

\u2022<\/span> <\/span>Major Adverse Cardiac Events (MACE): Risk may be increased in current\/past smokers and patients with other cardiovascular risk factors. Monitor for signs, evaluate and treat promptly. <\/span><\/span><\/p>\n

\u2022<\/span> <\/span>Thrombosis: Including deep venous thrombosis, pulmonary embolism, and arterial thrombosis may occur. Monitor for signs, evaluate and treat promptly. <\/span><\/span><\/p>\n

\u2022<\/span> <\/span>Secondary Malignancies: Lymphoma and other malignancies may occur. Past\/current smokers may be at increased risk. <\/span><\/span><\/p>\n

\u2022<\/span> <\/span>Risk of Infection: Delay starting LuciPac until active serious infections have resolved. Observe for signs and symptoms of infection and manage promptly<\/span>.<\/span><\/span><\/p>\n

 <\/span><\/p>\n

ADVERSE REACTIONS <\/span><\/strong><\/strong><\/span><\/p>\n

The most common (\u226520% of patients) adverse reactions are diarrhea, <\/span>thrombocytopenia, nausea, anemia, and peripheral edem<\/span>a.<\/span><\/span><\/p>\n

 <\/span><\/p>\n

DRUG INTERACTIONS <\/span><\/strong><\/strong><\/span><\/p>\n

Avoid use with moderate CYP3A4 inhibitors or inducers<\/span>.<\/span><\/span><\/p>\n

Coadministration of LuciPac can alter the concentration of drugs that are Pgp, BCRP, or OCT1 substrates. Avoid use with sensitive substra<\/span>tes.<\/span><\/span><\/p>\n

 <\/span><\/p>\n

USE IN SPECIFIC POPULATIONS <\/span><\/strong><\/strong><\/span><\/p>\n

Lactation: Advise not to breastfeed. <\/span><\/p>\n

Hepatic Impairment: Avoid use in moderate (Child-Pugh B) and severe hepatic impairment (Child-Pugh C) . <\/span><\/p>\n

Renal Impairment: Avoid use in patients with eGFR <30 mL\/mi<\/span>n.<\/span><\/span><\/p>\n

 <\/span><\/p>\n

Storage <\/span><\/strong><\/strong><\/span><\/p>\n

Store at 20<\/span>\u2103<\/span> to 25<\/span>\u2103<\/span> (68<\/span>\u2109<\/span> to 77<\/span>\u2109<\/span>), excursions permitted between 15<\/span>\u2103<\/span> and 30<\/span>\u2103<\/span> (59<\/span>\u2109<\/span> and 86<\/span>\u2109<\/span>) [see USP Controlled Room Temperature]. Protect from moisture. <\/span><\/span><\/p>\n

 <\/span><\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

LuciPac is a kinase inhibitor indicated for the treatment of adults with intermediate or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosi<\/p>","protected":false},"featured_media":1800,"comment_status":"open","ping_status":"closed","template":"","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":""},"product_brand":[],"product_cat":[21],"product_tag":[],"class_list":["post-598","product","type-product","status-publish","has-post-thumbnail","product_cat-blood-disease","first","instock","shipping-taxable","purchasable","product-type-simple"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/luciuspharmacy.com\/ru\/wp-json\/wp\/v2\/product\/598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/luciuspharmacy.com\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/luciuspharmacy.com\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/luciuspharmacy.com\/ru\/wp-json\/wp\/v2\/comments?post=598"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/luciuspharmacy.com\/ru\/wp-json\/wp\/v2\/media\/1800"}],"wp:attachment":[{"href":"https:\/\/luciuspharmacy.com\/ru\/wp-json\/wp\/v2\/media?parent=598"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/luciuspharmacy.com\/ru\/wp-json\/wp\/v2\/product_brand?post=598"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/luciuspharmacy.com\/ru\/wp-json\/wp\/v2\/product_cat?post=598"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/luciuspharmacy.com\/ru\/wp-json\/wp\/v2\/product_tag?post=598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}