{"id":234,"date":"2026-04-11T09:49:54","date_gmt":"2026-04-11T09:49:54","guid":{"rendered":"https:\/\/luciuspharmacy.com\/?post_type=product&p=234"},"modified":"2026-09-30T09:01:08","modified_gmt":"2026-09-30T09:01:08","slug":"lucicriz-crizotinib","status":"publish","type":"product","link":"https:\/\/luciuspharmacy.com\/zh\/product\/lucicriz-crizotinib\/","title":{"rendered":"\u514b\u5511\u66ff\u5c3c"},"content":{"rendered":"

HIGHLIGHTS OF PRESCRIBING INFORMATION <\/strong><\/span><\/p>\n

These highlights do not include all the information needed to use LUCICRIZ safely and effectively. See full prescribing information for LUCICRIZ.<\/strong><\/span><\/p>\n


<\/span><\/p>\n

INDICATIONS AND USAGE<\/strong><\/span><\/p>\n

LUCICRIZ is a kinase inhibitor indicated for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK) or ROS1-positive as detected by an FDA-approved test.<\/span><\/p>\n


<\/span><\/p>\n

DOSAGE AND ADMINISTRATION<\/strong><\/span><\/p>\n

 Recommended Dose: 250 mg orally, twice daily.  <\/span><\/p>\n

 Renal Impairment: 250 mg orally, once daily in patients with severe renal impairment (creatinine clearance<30 mL\/min) not requiring dialysis. <\/span><\/p>\n


<\/span><\/p>\n

DOSAGE FORMS AND STRENGTHS <\/strong><\/span><\/p>\n

Capsules: 250mg\u00d760 capsules<\/span><\/p>\n


<\/span><\/p>\n

CONTRAINDICATIONS <\/strong><\/span><\/p>\n

None.<\/span><\/p>\n


<\/span><\/p>\n

WARNINGS AND PRECAUTIONS <\/strong><\/span><\/p>\n

 Hepatotoxicity: Fatal hepatotoxicity occurred in 0.1% of patients. Monitor with periodic liver testing. Temporarily suspend, dose reduce, or permanently discontinue LUCICRIZ.<\/span><\/p>\n

 Interstitial Lung Disease (ILD)\/Pneumonitis: Occurred in 2.9% of patients. Permanently discontinue in patients with ILD\/pneumonitis.<\/span><\/p>\n

 QT Interval Prolongation: Occurred in 2.1% of patients. Monitor electrocardiograms and electrolytes in patients who have a history of or predisposition for QTc prolongation, or who are taking medications that prolong QT. Temporarily suspend, dose reduce, or permanently discontinue LUCICRIZ. <\/span><\/p>\n

 Bradycardia: LUCICRIZ can cause bradycardia. Monitor heart rate and blood pressure regularly. Temporarily suspend, dose reduce, or permanently discontinue LUCICRIZ.<\/span><\/p>\n

 Severe Visual Loss: Reported in 0.2% of patients. Discontinue LUCICRIZ in patients with severe visual loss. Perform an ophthalmological evaluation. <\/span><\/p>\n

 Embryo-Fetal Toxicity: Can cause fetal harm. Advise females of reproductive potential of the potential risk to a fetus and use of effective contraception.<\/span><\/p>\n


<\/span><\/p>\n

ADVERSE REACTIONS <\/strong><\/span><\/p>\n

The most common adverse reactions (\u226525%) are vision disorders, nausea, diarrhea, vomiting, edema, constipation, elevated transaminases, fatigue, decreased appetite, upper respiratory infection, dizziness, and neuropathy.<\/span><\/p>\n


<\/strong><\/span><\/p>\n

DRUG INTERACTIONS <\/strong><\/span><\/p>\n

 CYP3A Inhibitors: Avoid concurrent use of LUCICRIZ with strong CYP3A inhibitors. <\/span><\/p>\n

 CYP3A Inducers: Avoid concurrent use of LUCICRIZ with strong CYP3A inducers. <\/span><\/p>\n

 CYP3A Substrates: Avoid concurrent use of LUCICRIZ with CYP3A substrates with narrow therapeutic indices. <\/span><\/p>\n


<\/span><\/p>\n

USE IN SPECIFIC POPULATIONS <\/strong><\/span><\/p>\n

Lactation: Do not breastfeed while taking LUCICRIZ.<\/span><\/p>\n


<\/span><\/p>\n

Storage <\/strong><\/span><\/p>\n

Store at 20\u2103 to 25\u2103 (68\u2109 to 77\u2109), excursions permitted between 15\u2103 and 30\u2103 (59\u2109 and 86\u2109) [see USP Controlled Room Temperature]. Protect from moisture.<\/span><\/p>\n

<\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

LuciCriz contains crizotinib and is supplied as oral capsules. Please confirm the prescribed strength and review the full product information before ordering. A valid prescription and identity verification are required.<\/p>","protected":false},"featured_media":1837,"comment_status":"open","ping_status":"closed","template":"","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":""},"product_brand":[],"product_cat":[19],"product_tag":[],"class_list":["post-234","product","type-product","status-publish","has-post-thumbnail","product_cat-lung-cancer","first","instock","shipping-taxable","purchasable","product-type-simple"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/luciuspharmacy.com\/zh\/wp-json\/wp\/v2\/product\/234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/luciuspharmacy.com\/zh\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/luciuspharmacy.com\/zh\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/luciuspharmacy.com\/zh\/wp-json\/wp\/v2\/comments?post=234"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/luciuspharmacy.com\/zh\/wp-json\/wp\/v2\/media\/1837"}],"wp:attachment":[{"href":"https:\/\/luciuspharmacy.com\/zh\/wp-json\/wp\/v2\/media?parent=234"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/luciuspharmacy.com\/zh\/wp-json\/wp\/v2\/product_brand?post=234"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/luciuspharmacy.com\/zh\/wp-json\/wp\/v2\/product_cat?post=234"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/luciuspharmacy.com\/zh\/wp-json\/wp\/v2\/product_tag?post=234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}